Sodium Butyrate kana tributyrin'ndeipi yekusarudza'?

Zvinozivikanwa kuti butyric acid inzvimbo inokosha yesimba kumasero emudumbu. Uyezve, ndiyo inonyanya kufarirwa nemafuta uye inopa kusvika ku70% yesimba rayo rose. Zvisinei, kune marudzi maviri ekusarudza kubva. Chinyorwa chino chinopa kuenzanisa kwezvose zviri zviviri, zvichibatsira kupindura mubvunzo wekuti 'ndeipi yekusarudza'?

Kushandiswa kwebutyrate sechikafu chekuwedzera kwakadzidzwa zvakanyanya uye kwakashandiswa mukurima mhuka kwemakumi emakore akati wandei, kwakatanga kushandiswa mumhuru kukurudzira kukura kwehuremu hwemhuka isati yashandiswa munguruve nehuku.

Zvinowedzerwa zvebutyrate zvakaratidza kuti zvinovandudza kuwedzera kwehuremu hwemuviri (BWG) uye mwero wekuchinja kwekudya (FCR), zvinoderedza kufa uye zvinoderedza migumisiro yezvirwere zvine chekuita nedumbu.

Nzvimbo dzinowanikwa zvakanyanya dzebutyric acid yekudya kwemhuka dzinouya nenzira mbiri:

1. Semunyu (kureva Sodium butyrate) kana
2. Muchimiro che triglyceride (kureva Tributyrin).

Ipapo mubvunzo unotevera unouya -Ndinosarudza ipi?Chinyorwa chino chinopa kuenzanisa kwezvose zviri zviviri.

Maitiro ekugadzira

Sodium butyrate:Inogadzirwa kuburikidza ne acid-base reaction kuti igadzire munyu une poindi yakawanda yekunyunguduka.

NaOH+C4 H8 O2=C4 H7 COONa+H2O

(Sodium Hydroxide+Butyric Acid = Sodium Butyrate+Mvura)

Tributyrin:Inogadzirwa kuburikidza ne esterification apo 3 butyric acid inonamirwa ku glycerol kuti igadzire tributyrin. Tributyrin ine poindi shoma yekunyunguduka.

C3H8O3+3C4H8O2= C15 H26 O6+3H2O

(Glycerol+Butyric Acid = Tributyrin+Mvura)

Ndeipi inopa butyric acid yakawanda pa kg yezvigadzirwa?

KubvaTafura 1, tinoziva huwandu hwebutyric acid huri muzvigadzirwa zvakasiyana. Zvisinei, tinofanirawo kufunga kuti zvigadzirwa izvi zvinoburitsa butyric acid muura zvinobudirira sei. Sezvo sodium butyrate iri munyu, inonyungudika nyore nyore mumvura inoburitsa butyrate, saka tinogona kufunga kuti 100% yebutyrate kubva ku sodium butyrate ichaburitswa kana yanyungudika. Sezvo sodium butyrate ichingopatsanuka nyore nyore, mafomu akachengetedzwa (kureva micro-encapsulation) yesodium butyrate achaibatsira kuwana butyrate inononoka muura kusvika kudumbu.

Tributyrin chaizvoizvo itriacylglyceride (TAG), inova ester inobva kuglycerol ne3 fatty acids. Tributyrin inoda lipase kuti ibudise butyrate yakabatana neglycerol. Kunyangwe tributyrin imwe ine 3 butyrate, haisi 3 butyrate yese inovimbiswa kuburitswa. Izvi zvinodaro nekuti lipase inosarudzwa. Inogona hydrolyze triacylglycerides paR1 neR3, R2 chete, kana kuti kwete zvakananga. Lipase inewo substrate specificity pakuti enzyme inogona kusiyanisa pakati peacyl chains yakabatana neglycerol uye ichibvisa mamwe marudzi akasiyana. Sezvo tributyrin ichida lipase kuti ibudise butyrate yayo, panogona kunge paine makwikwi pakati petributyrin nedzimwe TAGs dze lipase.

Ko sodium butyrate netributyrin zvinokanganisa kudya kwemhuka here?

Sodium butyrate ine hwema hunokuvadza husingafadzi vanhu asi hunofarirwa nemhuka dzinoyamwisa. Sodium butyrate inoumba 3.6-3.8% yemafuta emukaka ari mumukaka wezamu, saka, inogona kushanda sechinhu chinokwezva chikafu zvichikonzera zvisikwa zvemhuka dzinoyamwisa kurarama (Tafura 2Zvisinei, kuti zvive nechokwadi chekuti mudumbu maburitswa zvishoma nezvishoma, sodium butyrate inowanzo putirwa nemafuta akawandisa (kureva Palm stearin). Izvi zvinobatsirawo kuderedza hwema hwe sodium butyrate.

Kune rumwe rutivi, Tributyrin haina hwema asi ine kuravira kunonetsa (Tafura 2). Kuwedzera huwandu hwakawanda kunogona kukanganisa kudya. Tributyrin imorekuru inogara yakasimba inogona kupfuura nemudumbu repamusoro kusvika yatsemuka ne lipase muura. Haichinji zvakare patembiricha yemumba, saka kazhinji haiputirwe. Tributyrin inowanzo shandisa silica dioxide isina simba semutakuri wayo. Silica dioxide ine maburi uye inogona kusaburitsa tributyrin zvizere panguva yekugaya. Tributyrin inewo vapor pressure yakakwira zvichiita kuti ive inochinjika kana yapiswa. Saka, tinokurudzira kuti tributyrin ishandiswe muchimiro chakasanganiswa kana muchimiro chakachengetedzwa.