Chinowedzera chikafu: Tributyrin

Zviri Mukati: 95%, 90%

Tributyrin sechikafu chinowedzera kunaka kwehuku.

Kurega kushandisa mishonga inorwisa mabhakitiriya senzira dzinokurudzira kukura kwemhuka kubva mukubika chikafu chehuku kwakawedzera kufarira nzira dzakasiyana dzekudya, dzekuwedzera mashandiro ehuku pamwe nekudzivirira kubva kuzvirwere.

Kuderedza kusagadzikana kwe dysbacteriosis
Kuti pave nekuongorora mamiriro ezvinhu e dysbacteriosis, zvinowedzera zvekudya zvakaita se probiotics uye prebiotics zviri kuwedzerwa kuti zvipesvedze kugadzirwa kweSCFAs, kunyanya butyric acid inoita basa guru mukudzivirira matumbo. Butyric acid iSCFA inowanikwa zvakasikwa ine zvakawanda zvinobatsira zvakaita sekudzivirira kuzvimba, simba rayo rekukurumidzisa kugadzirisa matumbo uye kukurudzira kukura kwe gut villi. Pane nzira yakasiyana iyo butyric acid inoshanda nayo kuburikidza nenzira yekudzivirira hutachiona, inonzi Host Defense Peptides (HDPs) synthesis, inozivikanwawo se anti-microbial peptides, izvo zvikamu zvakakosha zve innate immunity. Ine broad-spectrum anti-microbial activity kurwisa mabhakitiriya, fungi, parasite uye mavhairasi akaputirwa izvo zvinoomera zvikuru kuti hutachiona huve nekudzivirira. Defensins (AvBD9 & AvBD14) uye Cathelicidins ndiwo mhuri mbiri huru dzeHDPs (Goitsuka et al.; Lynn et al.; Ganz et al.) dzinowanikwa muhuku dzinowedzerwa ne butyric acid supplementation. Muchidzidzo chakaitwa naSunkara et. al. Kupiwa kwebutyric acid kubva kunze kunokonzera kuwedzera kukuru kwe HDP gene expression uye nokudaro kunowedzera kugona kwekudzivirira zvirwere muhuku. Zvinofadza kuti, pakati nepakati uye LCFAs zvishoma.

Mabhenefiti eTributyrin pahutano
Tributyrin inotangira butyric acid inobvumira mamorekuru akawanda ebutyric acid kuti aendeswe muura hudiki zvakananga nekuda kwehunyanzvi hwe esterification. Nokudaro, huwandu hwacho hwakakwira kaviri kusvika katatu kupfuura zvigadzirwa zvemazuva ose zvakaputirwa. Esterification inobvumira mamorekuru matatu ebutyric acid kusungirirwa kuglycerol iyo inogona kungoputswa chete ne endogenous pancreatic lipase.
Li et al. vakatanga chidzidzo chekudzivirira muviri kuti vawane mhedzisiro inobatsira ye tributyrin pama cytokines anodzivirira kuzvimba muma broilers ane LPS (lipopolysaccharide). Kushandiswa kweLPS kunozivikanwa zvakanyanya kuti kunokonzera kuzvimba muzvidzidzo zvakaita seizvi sezvo kuchiita kuti zviratidzo zvekuzvimba zvive seIL (Interleukins). Pamazuva 22, 24, uye 26 eongororo, broilers vakaedzwa nekupa 500 μg/kg BW LPS kana saline mukati medumbu. Kuwedzera tributyrin ye500 mg/kg kwakadzivirira kuwedzera kweIL-1β & IL-6 zvichiratidza kuti kuwedzerwa kwayo kunogona kuderedza kuburitswa kwema cytokines anodzivirira kuzvimba uye nokudaro kuderedza kuzvimba mumatumbu.

Pfupiso
Nekushandiswa kwakaganhurirwa kana kurambidzwa zvachose kwezvimwe zvinokurudzira kukura kwemishonga inorwisa mabhakitiriya sezvinowedzera zvekudya, nzira itsva dzekuvandudza nekuchengetedza hutano hwemhuka dzepurazi dzinofanira kuongororwa. Kusimba kwemukati kunoshanda sechinongedzo chakakosha pakati pezvinhu zvinodhura zvekudya uye kukurudzira kukura kwehuku dzehuku. Asidhi yebutyric inonyanya kuzivikanwa sechinosimudzira hutano hwemudumbu iyo yatove ichishandiswa mukudya kwemhuka kwemakore anopfuura makumi maviri. Tributyrind inopa butyric acid muura hudiki uye inoshanda zvikuru mukugadzirisa hutano hwemudumbu nekukurumidzisa maitiro ekugadzirisa mudumbu, kukurudzira kukura kwevilli yakakwana uye kugadzirisa maitiro ekudzivirira muviri mudumbu.

Zvino sezvo mushonga wekuuraya utachiona uri kubviswa, asidhi yebutyric chishandiso chikuru chekutsigira indasitiri kuderedza mhedzisiro yakaipa ye dysbacteriosis iri kubuda nekuda kwekuchinja uku.