Dzimwe nzira dzekurapa dzinodiwa panzvimbo pemishonga inorwisa mabhakitiriya nekuda kwekurambidzwa kwekushandiswa kwemishonga iyi senzira dzinokurudzira kukura kwemhuka dzinodya chikafu. Tributyrin inoita seinobatsira mukuvandudza kukura kwenguruve, kunyangwe ichishanda zvakasiyana-siyana.

Kusvika pari zvino, hapana zvakawanda zvinozivikanwa nezvemhedzisiro yayo pakugadzirwa kwe microbiota mudumbu. Muchidzidzo ichi, takaongorora shanduko dze microbiota mudumbu dzevana vadiki, vachigamuchira, 0.2% tributyrin inowedzerwa mukudya kwavo kwekutanga.

Boka reTributyrin raiva nekwaniso yakakura yekushandiswa kwesimba uye mukana mudiki wekushandiswa kwemakabhohaidhiretsi. Mukupedzisa, zvatakawana zvakaratidza kuti tributyrin inogona kukurudzira shanduko kunharaunda dzemabhakitiriya mudumbu, izvo zvinogona kubatsira mukuvandudza mashandiro emhuka mushure mekurumurwa.

Zvinokonzera Tributyrin paMashanduko eMatumbu Microbiota Ane Chekuita neKurumurwa kweNguruve Dzichiri Kuberekwa

Zvimiro zveChigadzirwa

Tributyrin (inonziwo Glyceryl tributyrate; Glycerol tributyrate; Glycery tributyrate; propane-1,2,3-triyl tributanoate), rudzi rwe short chain fatty acid ester.

CAS RN: 60-01-5

Nhamba yeEINECS: 200-451-5

Fomura: C15H26O6

Nhamba yeFW: 302.36

Chitarisiko: Imvura ine mafuta machena kusvika eyero ine hwema hwakakora zvishoma.

Kunyungudika: inonyungudika mu ethanol, chloroform uye ether, hainyungudike zvakanyanya mumvura (0.010%).

Hupenyu hweSherufu: Mwedzi makumi maviri nemana

Pasuru: 25KG/ Bhegi

Kuchengetera: Yakavharwa munzvimbo dzakaoma uye dzine mhepo inofefetera

Tributyrini triglyceride ine mamorekuru matatu e butyrate akasanganiswa kuita glycerol, inowedzera huwandu hwe butyrate mushure mekunyungudika kwe hydrolyzation ne pancreatic lipases.

Hunhu hweTributyrin
Chizvarwa chitsva chebutyrate-glycerol ester yebutyric acid.
100% bvisa dumbu.
Inoendesa asidhi yebutyric muura hudiki, haidi kuputirwa.
Zvinowanzoitika kuti inowanikwa mumukaka neuchi.

Kuenzanisa Pakati peTributyrin neButyrate Munyu

Hafu yehupenyu hwebutyric acid maminetsi matanhatu. Butyrate inonetsa kusvika kune dzimwe nhengo nenyama dziri kunze kweura inopihwa muchimiro chebutyric acid kana butyrate. Zvisinei, hafu yehupenyu hwetributyrin maminetsi makumi mana, uye huwandu hwebutyrate muplasma hunogona kuramba huri pamusoro pe0.1mM kwemaawa 0.5-4 nemuromo.

Maitiro & Zvimiro

Mutengesi weSimba

Sezvinozivikanwa, butyric acid ifuruu pfupi inova ndiyo sosi huru yesimba remasero emudumbu. Inopfuura 70% yesimba rekukura kwemasero emudumbu rinowanikwa nebutyric acid. Zvisinei, tributyrin inopa butyric acid inoburitsa ura hwakanyanya kupfuura dzimwe zvigadzirwa zvebutyrate.

Dziviriro yeMatumbu

►Tributyrin inokurudzira kuwanda nekusiyanisa masero emudumbu, inogadzirisa mucosa yakakuvara, uye inowedzera nzvimbo yepamusoro kuti iwane zvinovaka muviri.

►Tributyrin inokurudzira kuburitswa kwemapuroteni e tight junction mudumbu, inochengetedza kubatanidzwa kwakasimba pakati pemasero, inodzivirira macromolecules akadai semabhakitiriya nehupfu kuti asapinde mumuviri, uye inochengetedza mashandiro emuviri ekudzivirira dumbu.

►Tributyrin inokurudzira kuburitswa kwemucin (Muc) uye inosimbisa mashandiro ekudzivirira makemikari mudumbu.

Mwero weKupona Wavandudzika

Tributyrin inogona kukurudzira kugadzirwa kwehemoglobin, kuvandudza kugona kwekutakura okisijeni, kusimbisa sisitimu yekutsigira hupenyu hwemuviri, uye inogona kuvandudza mashandiro emitochondria uye kukurudzira kugadzirwa kweATP, chinhu chinosimudzira hupenyu, kuitira kuvandudza mwero wekurarama kwemhuka.

Anti-Inflammatory & Antibacterial

►Nekudzivisa kushanda kweNF-Kb, TNF-α uye TLR, Tributyrin inogona kuderedza kukuvara kwekuzvimba.

►Tributyrin inokurudzira kuratidzwa kwemapeptide ekudzivirira endogenous, ayo anogona kurwisa utachiona nehutachiona zvakanyanya.