Guanylacetic acid, inozivikanwawo se guanylacetic acid, i amino acid analogue inoumbwa kubva ku glycine ne L-lysine.

Guanylacetic acid inogona kugadzira creatine pasi pe catalysis yema enzymes uye ndiyo chete inodiwa kuti creatine iite. Creatine inozivikanwa se energy buffer, uye basa rayo guru nderekuumba phosphorylated creatine pasi pe creatine kinase.

Tora chikamu murwendo rwe adenosinekutenderera kwehosphate (ATP). Kana simba reATP risina kukwana, phosphocreatine inokurumidza kutamisa boka rephosphate kuadenosine diphosphate kuburikidza necreatine kinase uye inoridzorera kuadenosine triphosphate.

 

Kushandiswa muzvipfuyo zvinodya nyama:

Kuwedzera 0.12%, 0.08%, uye 0.04% guanylacetic acid pakudya kwemakwai zana nemakumi maviri akadyiswa mombe dzeTan dzairema makirogiramu makumi maviri zvichiteerana, kwakaratidza kuti kuwedzerwa kwe0.12% ne0.08% guanylacetic acid kwakawedzera zvakanyanya kuwedzera huremu hwezuva nezuva, mafuta emudumbu, uye mapuroteni, uye kuderedza zvakanyanya mafuta emutumbi.

 

Kuwedzera kwe0.08%guanylacetic acidKuwedzerwa kwehuwandu hwenyama ne9.77%. Nekushandisa nzira yekugadzira gasi mu vitro, mhedzisiro yekuwedzera huwandu hwakasiyana hwe guanylacetic acid padumbu remombe dzeyellow yakaongororwa. Zvakaonekwa kuti kuwedzerwa kwe 0.4% guanylacetic acid kwakawedzera zvakanyanya kugadzirwa kwegasi, uye huwandu hwe ammonia nitrogen hwakatanga hwawedzera uye hwakaderera.

Saka, zvinogona kufungidzirwa kuti kuwedzera guanylacetic acid muchikafu chezuva nezuva kunogona kuvandudza mamiriro emukati merumen uye nzira yekuvirisa mombe dzeyero.

Kushandiswa muhuku:

Kuwedzera 800 mg/kg, 1600 mg/kg, 4000 mg/kg, uye 8000 mg/kg yeguanylacetic acid muchikafu chezuva nezuva chehuku dzemombe kwakaratidza kuti kuwedzera 800-4000 mg/kg yeguanylacetic acid muchikafu kwakawedzera zvakanyanya kuwedzera kwehuremu hwehuku dzemombe zuva nezuva, kwakaderedza chiyero chehuku dzemombe kusvika pakurema pamazuva 22-42 ekuberekwa. Kuwedzera 8000 mg/kg yeguanylacetic acid kwakavandudza zviratidzo zvebiochemical muropa zvakaita seurea nitrogen, zviratidzo zveropa, uye total bilirubin Hapana chakachinja zvakanyanya zviratidzo zvikuru zvenhengo dzemuviri, zvichiratidza kuti kuwedzera 8000 mg/kg yeguanylacetic acid muchikafu chezuva nezuva chehuku dzemombe kunobvumirwa.

Kuwedzera 200 mg/kg, 400 mg/kg, 600 mg/kg, uye 800 mg/kg yeguanylacetic acid muchikafu chemombe dzemombe kwakaratidza kuwedzera kukuru kwehuremu hwezuva nezuva zvichienzaniswa neboka rekutarisira. Mhedzisiro yakanakisisa yakawanikwa apo huwandu hwekuwedzera hwaive 600 uye 800 mg/kg.

Kuti vadzidze nezvemhedzisiro ye guanylacetic acid pahunhu hwembeu mumajongwe, majongwe makumi maviri ane mavhiki makumi maviri nemasere akasarudzwa kuti ape chikafu chine 0%, 0.06%, 0.12%, uye 0.18% guanylacetic acid. Mhedzisiro yekutsvagisa yakawana kuti kuwedzera 0.12% guanylacetic acid mukudya kwakawedzera zvakanyanya huwandu hwembeu, huwandu hwembeu, uye mashandiro embeu mumajongwe, zvichiratidza kuti kuwedzera guanylacetic acid mukudya kunogona kuvandudza hunhu hwembeu. Wedzera 0.0314%, 0.0628%, 0.0942%, uye 0.1256% guanylacetic acid mukudya kwembeu kwezuva nezuva, uye gadza mapoka maviri ekudzora (boka rekudzora 1 chikafu chezvirimwa chisina chinhu chakawedzerwa, uye boka rekudzora 2 chikafu chine chikafu chehove chakawedzerwa). Mapoka matanhatu ari pamusoro ekudya kwezuva nezuva ane simba nemaminerari akafanana.

Mhedzisiro yekuyedza inoratidza kuti mwero wekuwedzera huremu hwemapoka mana ane guanylacetic acid yakawedzerwa uye boka rekutonga rechipiri wakakwira kupfuura weboka rekutonga re1, Boka rekutonga re2 raive nemhedzisiro yakanakisa yekuwedzera huremu, richiteverwa neboka re0.0942% guanylacetic acid; Boka rekutonga re2 raive nechiyero chakanakisa chezvinhu nehuremu, richiteverwa neboka re0.1256% guanylacetic acid.

Kushandiswa muhuku:

Kuwedzera 800 mg/kg, 1600 mg/kg, 4000 mg/kg, uye 8000 mg/kg yeguanylacetic acidKudya kwehuku dzenyama zuva nezuva kwakaratidza kuti kuwedzera 800-4000 mg/kg yeguanylacetic acid mukudya kwakawedzera zvakanyanya kuwedzera kwehuremu hwehuku dzenyama zuva nezuva, kuderedza chiyero chehuku dzenyama kusvika pahuremu hwehuku pazera remazuva 22-42. Kuwedzera 8000 mg/kg yeguanylacetic acid kwakavandudza zviratidzo zve biochemical muropa zvakaita se urea nitrogen, zviratidzo zveropa, uye total bilirubin. Hapana chakachinja zvakanyanya zviratidzo zvikuru zvenhengo, zvichiratidza kuti kuwedzera 8000 mg/kg yeguanylacetic acid mukudya kwehuku kwezuva nezuva kunobvumirwa. Kuwedzera 200 mg/kg, 400 mg/kg, 600 mg/kg, uye 800 mg/kg yeguanylacetic acid mukudya kwehuku kwenyama kwakaratidza kuwedzera kukuru kweavhareji yehuremu hwenyama zuva nezuva zvichienzaniswa neboka rekutonga. Mhedzisiro yakanaka yakawanikwa apo huwandu hwekuwedzera hwaive 600 uye 800 mg/kg.

Kuti vadzidze nezvemhedzisiro ye guanylacetic acid pahunhu hwembeu mumajongwe, majongwe makumi maviri ane mavhiki makumi maviri nemasere akasarudzwa kuti ape chikafu chine 0%, 0.06%, 0.12%, uye 0.18% guanylacetic acid. Mhedzisiro yekutsvagisa yakawana kuti kuwedzera 0.12% guanylacetic acid mukudya kwakawedzera zvakanyanya huwandu hwembeu, huwandu hwembeu, uye mashandiro embeu mumajongwe, zvichiratidza kuti kuwedzera guanylacetic acid mukudya kunogona kuvandudza hunhu hwembeu. Wedzera 0.0314%, 0.0628%, 0.0942%, uye 0.1256% guanylacetic acid mukudya kwembeu kwezuva nezuva, uye gadza mapoka maviri ekudzora (boka rekudzora 1 chikafu chezvirimwa chisina chinhu chakawedzerwa, uye boka rekudzora 2 chikafu chine chikafu chehove chakawedzerwa). Mapoka matanhatu ari pamusoro ekudya kwezuva nezuva ane simba nemaminerari akafanana. Mhedzisiro yekuyedza inoratidza kuti mwero wekuwedzera uremu wemapoka mana ane guanylacetic acid yakawedzerwa uye boka rekudzora rechipiri wakakwira kupfuura weboka rekudzora re1, Boka rekudzora re2 raive nemhedzisiro yakanaka yekuwedzera uremu, richiteverwa ne0.0942%guanylacetic acidboka rekutonga rechipiri raiva nechiyero chakanakisa chehuremu hwezvinhu, richiteverwa neboka re0.1256% guanylacetic acid.