PfupisoKuedza kwakaitwa kuti kudzidze mhedzisiro ye diludine pakuita kwekuisa mazai uye kunaka kwemazai muhuku uye nzira yekuona mashandiro emhedzisiro yacho nekuona indekisi dzemazai ne serum parameters 1024 Huku dzeROM dzakakamurwa kuita mapoka mana rimwe nerimwe raisanganisira mana akatorwa ehuku 64 imwe neimwe, Mapoka ekurapa akagamuchira kudya kwakafanana kwekutanga kwakawedzerwa ne 0, 100, 150, 200 mg/kg diludine zvakateerana kwe80 mazuva. Mhedzisiro yacho yaive seinotevera. Kuwedzera diludine mukudya kwakavandudza kuita kwekuisa mazai ehuku, uko kurapwa kwe 150 mg/kg kwaive kwakanakisa; mwero wayo wekubereka wakawedzerwa ne 11.8% (p< 0.01), kushandurwa kwehuwandu hwemazai kwakadzikira ne 10.36% (p< 0 01). Huremu hwemazai hwakawedzerwa nekuwedzera kwe diludine yakawedzerwa. Diludine yakaderedza zvakanyanya huwandu hwe uric acid mu serum (p< 0.01); kuwedzera diludine kwakaderedza zvakanyanya Ca mu serum.2+uye inorganic phosphate content, uye kuwedzera kwekushanda kwealkine phosphatase (ALP) yeropa (p< 0.05), saka zvakabatsira zvikuru pakuderedza kutyoka kwezai (p< 0.05) uye kusagadzikana (p< 0.05); diludine yakawedzera zvakanyanya kukwirira kwe albumen. Haugh value (p< 0.01), ukobvu hweganda nehuremu hweganda (p< 0.05), 150 uye 200mg/kg diludine yakaderedzawo total choleasterol mu zai yolk (p< 0 05), asi yakawedzera huremu hwe zai yolk (p< 0.05). Pamusoro pezvo, diludine inogona kuwedzera kushanda kwe lipase (p< 0.01), uye kuderedza huwandu hwe triglyceride (TG3) (p< 0.01) uye cholesterol (CHL) (p< 0 01) muropa, yakaderedza huwandu hwemafuta emudumbu (p< 0.01) uye huwandu hwemafuta echiropa (p< 0.01), yaive nekwanisi yekudzivirira huku kubva pachiropa chine mafuta. Diludine yakawedzera zvakanyanya kushanda kweSOD muropa (p<0 01) payakawedzerwa mukudya kweanopfuura mazuva makumi matatu. Zvisinei, hapana musiyano wakakosha wakawanikwa mukushanda kweGPT neGOT muropa pakati peboka rekutonga nerakarapwa. Zvakafungidzirwa kuti diludine inogona kudzivirira membrane yemasero kubva mukuoxidation.
Mashoko akakoshaDiludine; huku; SOD; cholesterol; triglyceride, lipase
Diludine ivhitamini itsva isingadyi muviri inorwisa oxidation uye ine mhedzisiro[1-3]yekudzora oxidation ye membrane yemuviri uye kudzikamisa tishu dzemasero emuviri, nezvimwewo. Muma1970, nyanzvi yezvekurima yekuLatvia muSoviet Union yaimbove yakawana kuti diludine ine mhedzisiro[4]yekukurudzira kukura kwehuku uye kudzivirira kuomeswa nechando uye kukwegura kwezvimwe zvirimwa. Zvakataurwa kuti diludine haingogone kukurudzira kukura kwemhuka chete, asiwo inovandudza kubereka kwemhuka zviri pachena uye inovandudza mwero wekubata pamuviri, kuburitsa mukaka, kuburitsa mazai uye mwero wekuzvara kwemhuka hadzi.[1, 2, 5-7]Chidzidzo che diludine muChina chakatangwa kubva kuma1980, uye ruzhinji rwezvidzidzo nezve diludine muChina zvakangoshandiswa chete kusvika pari zvino, uye miedzo mishomanana pakuisa huku yakashumwa. Chen Jufang (1993) akataura kuti diludine inogona kuvandudza kubuda kwezai nehuremu hwezai rehuku, asi haina kudzika.[5]kudzidza mashandiro azvo. Saka, takaita ongororo yakarongeka yemhedzisiro yacho nekupa huku dzinoyamwisa chikafu chakawedzerwa diludine, uye chimwe chikamu chemhedzisiro yacho ikozvino chataurwa seinotevera:
Tafura 1. Kuumbwa uye zvinovaka muviri zvekudya kwekuyedza
%
-- ...
Kuumbwa kwezvikamu zvekudya zvine hutano
-- ...
Chibage 62 ME③ 11.97
Nyama yebhinzi 20 CP 17.8
Hupfu hwehove 3 Ca 3.42
Upfu hwembeu yerapeseed 5 P 0.75
Bone kudya 2 M et 0.43
Kudya kwematombo 7.5 M uye Cys 0.75
Methionine 0.1
Munyu 0.3
Multivitamin① 10
Zvinhu zvinoteverwa② 0.1
-- ...
① Multivitamin: 11mg ye riboflavin, 26mg ye folic acid, 44mg ye oryzanin, 66mg ye niacin, 0.22mg ye biotin, 66mg ye B6, 17.6ug ye B12, 880mg ye choline, 30mg ye VK, 66IU ye VE, 6600ICU yeVDuye 20000ICU yeVA, zvinowedzerwa pakirogiramu yega yega yekudya; uye 10g multivitamin inowedzerwa pakirogiramu yega yega yekudya kwe50kg.
② Zvinhu zvinotevedzana (mg/kg): 60 mg yeMn, 60mg yeZn, 80mg yeFe, 10mg yeCu, 0.35mg yeI uye 0.3mg yeSe zvinowedzerwa pakirogiramu yega yega yekudya.
③ Chikamu chesimba rinogadziriswa chinoreva MJ/kg.
1. Zvinhu uye nzira
1.1 Zvinhu zvekuyedza
Beijing Sunpu Biochem. & Tech. Co., Ltd. inofanira kupa diludine; uye mhuka yekuedza inofanira kureva huku dzeRoma dzinoita zvekutengesa dzine mazuva mazana matatu ekuberekwa.
Kudya kwekuyedza: Kudya kwekuyedza kwekuyedza kunofanirwa kugadzirwa zvichienderana nemamiriro chaiwo panguva yekugadzira zvichibva pachiyero cheNRC, sezvakaratidzwa muTafura 1.
1.2 Nzira yekuyedza
1.2.1 Kuedza kudya: kuyedza kudya kunofanirwa kuitwa mupurazi reHongji Company muJiande City; huku dzeRoma dzinoisa mazai dzinofanira kusarudzwa dzokamurwa kuita mapoka mana zvisina tsarukano uye imwe neimwe iine zvidimbu 256 (boka rega rega rinofanira kudzokororwa ka4, uye huku yega yega inofanira kudzokororwa ka64); huku dzinofanira kudyiswa kudya kwakasiyana kwe diludine, uye 0, 100, 150, 200mg/kg yekudya kunofanira kuwedzerwa kuboka rega rega. Kuedza kwakatanga musi wa10 Kubvumbi, 1997; uye huku dzaigona kuwana chikafu uye kunwa mvura zvakasununguka. Chikafu chinotorwa neboka rega rega, mwero wekukandira, kubuda kwezai, zai rakatyoka uye huwandu hwezai risina kujairika zvinofanira kunyorwa. Uyezve, bvunzo yakapera musi wa30 Chikumi, 1997.
1.2.2 Kuyerwa kwemhando yezai: Mazai makumi maviri anofanira kutorwa zvisina tsarukano pakaitwa bvunzo iyi mazuva mana makumi mana kuitira kuyera zviratidzo zvine chekuita nemhando yezai, zvakaita se indekisi yechimiro chezai, chikamu chehaugh, huremu hwegoko, ukobvu hwegoko, indekisi yeyolk, huremu hweyolk, nezvimwewo. Uyezve, huwandu hwecholesterol muyolk hunofanira kuyerwa nekushandisa nzira yeCOD-PAP paine Cicheng reagent yakagadzirwa neNingbo Cixi Biochemical Test Plant.
1.2.3 Kuyerwa kwechiyero chemakemikari muropa: Huku gumi nenhanhatu dzinofanira kutorwa kubva muboka rega rega nguva imwe neimwe apo bvunzo yakaitwa kwemazuva makumi matatu uye kana bvunzo yapera kugadzirira seramu mushure mekutorwa ropa kubva mutsinga iri pabapiro. Seramu inofanira kuchengetwa patembiricha yakaderera (-20℃) kuitira kuyera chiyero chemakemikari chakakodzera. Chikamu chemafuta emudumbu uye huwandu hwemafuta muchiropa zvinofanira kuyerwa mushure mekuuraya nekubvisa mafuta emudumbu nechiropa mushure mekutorwa kweropa.
Superoxide dismutase (SOD) inofanira kuyerwa nekushandisa nzira yekuzara kwemasero aripo pamberi pe reagent kit yakagadzirwa neBeijing Huaqing Biochem. & Tech. Research Institute. Uric acid (UN) iri mu serum inofanira kuyerwa nekushandisa nzira yeU ricase-PAP pamberi pe Cicheng reagent kit; triglyceride (TG3) inofanira kuyerwa nekushandisa GPO-PAP nzira imwe chete pamberi pe Cicheng reagent kit; lipase inofanira kuyerwa nekushandisa nephelometry pamberi pe Cicheng reagent kit; serum total cholesterol (CHL) inofanira kuyerwa nekushandisa nzira yeCOD-PAP pamberi pe Cicheng reagent kit; glutamic-pyruvic transaminase (GPT) inofanira kuyerwa nekushandisa colorimetry pamberi pe Cicheng reagent kit; glutamic-oxalacetic transaminase (GOT) inofanira kuyerwa nekushandisa colorimetry pamberi pe Cicheng reagent kit; alkaline phosphatase (ALP) inofanira kuyerwa uchishandisa nzira yekuyera kana paine Cicheng reagent kit; calcium ion (Ca2)2+() mu serum inofanira kuyerwa nekushandisa methylthymol blue complex. Imwe nzira iripo paine Cicheng reagent kit; inorganic phosphorus (P) inofanira kuyerwa nekushandisa molybdate blue method paine Cicheng reagent kit.
2 Mhedzisiro yebvunzo
2.1 Mhedzisiro pakushanda zvakanaka kwekuisa
Maitiro ekuisa mapombi emapoka akasiyana akagadzirwa nekushandisa diludine anoratidzwa muTafura 2.
Tafura 2 Mashandiro anoita huku dzakapihwa chikafu chekutanga chine huwandu huna hwe diludine
| Huwandu hwe diludine hunofanira kuwedzerwa (mg/kg) | ||||
| 0 | 100 | 150 | 200 | |
| Kudya kwezvikafu (g) |  | |||
| Mwero wekuiswa (%) | ||||
| Huremu hweavhareji yezai (g) | ||||
| Chiyero chezvinhu nezai | ||||
| Mwero wemazai akatyoka (%) | ||||
| Mwero wezai risina kujairika (%) | ||||
Kubva paTafura 2, mwero wekuiswa kwembeu mumapoka ese anogadzirwa nekushandisa diludine wavandudzika zviri pachena, uko mhedzisiro kana ichigadziriswa nekushandisa 150mg/kg iri nani (kusvika 83.36%), uye 11.03% (p<0.01) inovandudzika zvichienzaniswa neboka revanotaridza; saka diludine ine mhedzisiro yekuvandudza mwero wekuiswa kwembeu. Zvichionekwa kubva paavhareji yehuremu hwezai, huremu hwezai huri kuwedzera (p>0.05) pamwe nekuwedzera kwediludine mukudya kwezuva nezuva. Zvichienzaniswa neboka revanotaridza, musiyano pakati pezvikamu zvese zvinogadzirwa zvemapoka anotaridzwa nekushandisa 200mg/kg yediludine hausi pachena kana 1.79g yekudya inowedzerwa paavhareji; Zvisinei, musiyano unova pachena zvishoma nezvishoma pamwe chete nekuwedzera kwe diludine, uye musiyano wehuwandu hwezvinhu nemazai pakati pezvikamu zvinogadzirwa unooneka (p<0.05), uye mhedzisiro yacho yakanaka kana 150mg/kg ye diludine iri 1.25:1 iyo inoderedzwa ne10.36% (p<0.01) zvichienzaniswa neboka rekutarisa. Zvichionekwa kubva pahuwandu hwezai rakaputsika hwezvikamu zvese zvinogadzirwa, huwandu hwezai rakaputsika (p<0.05) hunogona kuderedzwa kana diludine yawedzerwa pakudya kwezuva nezuva; uye huwandu hwemazai asina kujairika hunoderedzwa (p<0.05) pamwe nekuwedzera kwe diludine.
2.2 Mhedzisiro yemhando yezai
Kubva paTafura 3, chimiro chezai uye simba remudumbu hazvikanganisike (p>0.05) kana diludine yawedzerwa pakudya kwezuva nezuva, uye huremu hwegoko hunowedzerwa pamwe chete nekuwedzera kwediludine pakudya kwezuva nezuva, apo huremu hwegoko hunowedzerwa ne10.58% uye 10.85% (p<0.05) zvichiteerana zvichienzaniswa nemapoka ereferensi apo 150 ne200mg/kg yediludine zvinowedzerwa; ukobvu hwegoko rezai hunowedzerwa pamwe chete nekuwedzera kwediludine pakudya kwezuva nezuva, apo ukobvu hwegoko rezai hunowedzerwa ne13.89% (p<0.05) apo 100mg/kg yediludine inowedzerwa zvichienzaniswa nemapoka ereferensi, uye ukobvu hwegoko rezai hunowedzerwa ne19.44% (p<0.01) uye 27.7% (p<0.01) zvichiteerana kana 150 ne200mg/kg zvawedzerwa. Chikamu cheHaugh (p<0.01) chinovandudzika zviri pachena kana diludine yawedzerwa, izvo zvinoratidza kuti diludine ine simba rekusimudzira kugadzirwa kwe albumen yakakora yezai jena. Diludine ine basa rekuvandudza index ye yolk, asi musiyano hausi pachena (p<0.05). Zviri mukati me cholesterol yezai yolk yemapoka ese zvakasiyana uye zvinogona kuderedzwa zviri pachena (p<0.05) mushure mekuwedzera 150 ne200mg/kg ye diludine. Huremu hwezai yolk hwakasiyana kubva kune mumwe nemumwe nekuda kwehuwandu hwakasiyana hwe diludine hwakawedzerwa, apo huremu hwezai yolk hunovandudzwa ne18.01% ne14.92% (p<0.05) kana 150mg/kg ne200mg/kg zvichienzaniswa neboka rekutarisa; saka, diludine yakakodzera ine simba rekusimudzira kugadzirwa kwezai yolk.
Tafura 3 Mhedzisiro ye diludine pamhando yezai
| Huwandu hwe diludine hunofanira kuwedzerwa (mg/kg) | ||||
| Hunhu hwezai | 0 | 100 | 150 | 200 |
| Chimiro chechimiro chezai (%) |  | |||
| Simba remazai (g/cm3) | ||||
| Huremu hwegoko rezai (%) | ||||
| Ukobvu hwegoko rezai (mm) | ||||
| Chikamu chekuseka (U) | ||||
| Nhamba yezai (%) | ||||
| Cholesterol yemuzai (%) | ||||
| Huremu hwezai rakaenzana (%) | ||||
2.3 Mhedzisiro pahuwandu hwemafuta emudumbu uye huwandu hwemafuta echiropa ehuku dzinoyamwisa
Ona Mufananidzo 1 neMufananidzo 2 kuti uwane mhedzisiro ye diludine pahuwandu hwemafuta emudumbu uye huwandu hwemafuta echiropa ehuku dzinoyamwisa.
Mufananidzo 1 Mhedzisiro ye diludine pahuwandu hwemafuta emudumbu (PAF) ehuku dzinokandira mazai
| Chikamu chemafuta emudumbu | |
| Huwandu hwe diludine hunofanira kuwedzerwa |
Mufananidzo 2 Mhedzisiro ye diludine pahuwandu hwemafuta echiropa (LF) ehuku dzinokandira mazai
| Mafuta ari muchiropa | |
| Huwandu hwe diludine hunofanira kuwedzerwa |
Kubva paMufananidzo 1, huwandu hwemafuta emudumbu eboka rekuyedza hunoderedzwa ne8.3% uye 12.11% (p<0.05) zvichiteerana kana 100 ne150mg/kg yediludine zvichienzaniswa neboka rekutarisa, uye huwandu hwemafuta emudumbu hunoderedzwa ne33.49% (p<0.01) kana 200mg/kg yediludine yawedzerwa. Kubva paMufananidzo 2, huwandu hwemafuta emuchiropa (akaoma zvachose) akagadziriswa ne100, 150, 200mg/kg yediludine zvichiteerana hunoderedzwa ne15.00% (p<0.05), 15.62% (p<0.05) uye 27.7% (p<0.01) zvichiteerana zvichienzaniswa neboka rekutarisa; saka, diludine ine simba rekuderedza huwandu hwemafuta emudumbu uye huwandu hwemafuta echiropa ari muchikamu chekuisa zviri pachena, apo mhedzisiro yacho inonyanya kunaka kana 200mg/kg yediludine ikawedzerwa.
2.4 Mhedzisiro kune serum biochemical index
Kubva paTafura 4, musiyano uripo pakati pezvikamu zvakagadziriswa panguva yeKuyedzwa kweSOD kweChikamu I (30d) hausi pachena, uye huwandu hwemakemikari muropa hwemapoka ese akawedzerwa diludine muChikamu II (80d) chebvunzo hwakakwirira kupfuura boka rekutarisa (p<0.05). Uric acid (p<0.05) muropa inogona kuderedzwa kana 150mg/kg uye 200mg/kg yediludine yawedzerwa; nepo mhedzisiro (p<0.05) iripo kana 100mg/kg yediludine yawedzerwa muChikamu I. Diludine inogona kuderedza triglyceride muropa, apo mhedzisiro yacho yakanaka (p<0.01) muboka kana 150mg/kg yediludine yawedzerwa muChikamu I, uye yakanaka muboka kana 200mg/kg yediludine yawedzerwa muChikamu II. Cholesterol yese muropa inodzikira kana diludine yakawedzerwa mukudya kwezuva nezuva, kunyanya zviri muropa rose zvinodzikira ne36.36% (p<0.01) uye 40.74% (p<0.01) zvichiteerana kana 150mg/kg uye 200mg/kg yediludine zvawedzerwa muPhase I zvichienzaniswa neboka rekutarisa, uye zvinodzikira ne26.60% (p<0.01), 37.40% (p<0.01) uye 46.66% (p<0.01) zvichiteerana kana 100mg/kg, 150mg/kg uye 200mg/kg yediludine zvawedzerwa muPhase II zvichienzaniswa neboka rekutarisa. Uyezve, ALP inowedzera kana diludine yakawedzerwa pakudya kwezuva nezuva, nepo kukosha kweALP muboka rine 150mg/kg uye 200mg/kg yediludine kwakakwira kupfuura boka rekutarisa (p<0.05) zviri pachena.
Tafura 4 Mhedzisiro ye diludine pamatanho e serum
| Huwandu hwe diludine hunofanira kuwedzerwa (mg/kg) muchikamu chekutanga (mazuva makumi matatu) chebvunzo. | ||||
| Chinhu | 0 | 100 | 150 | 200 |
| Superoxide dismutase (mg/mL) |  | |||
| Asidhi yeUric | ||||
| Triglyceride (mmol/L) | ||||
| Lipase (U/L) | ||||
| Cholesterol (mg/dL) | ||||
| Glutamic-pyruvic transaminase (U/L) | ||||
| Glutamic-oxalacetic transaminase (U/L) | ||||
| Alkaline phosphatase (mmol/L) | ||||
| Ioni yecalcium (mmol/L) | ||||
| Phosphorus isina kuumbwa (mg/dL) | ||||
| Huwandu hwe diludine hunofanira kuwedzerwa (mg/kg) muChikamu chechipiri (80d) chebvunzo | ||||
| Chinhu | 0 | 100 | 150 | 200 |
| Superoxide dismutase (mg/mL) |  | |||
| Asidhi yeUric | ||||
| Triglyceride (mmol/L) | ||||
| Lipase (U/L) | ||||
| Cholesterol (mg/dL) | ||||
| Glutamic-pyruvic transaminase (U/L) | ||||
| Glutamic-oxalacetic transaminase (U/L) | ||||
| Alkaline phosphatase (mmol/L) | ||||
| Ioni yecalcium (mmol/L) | ||||
| Phosphorus isina kuumbwa (mg/dL) | ||||
3 Kuongorora nekukurukurirana
3.1 Diludine mubvunzo yakavandudza mwero wekukandira mazai, huremu hwezai, chikamu cheHaugh uye huremu hwezai, izvo zvakaratidza kuti diludine ine mhedzisiro yekukurudzira kuunganidzwa kweprotein uye kuvandudza huwandu hwealbumen yakakora yezai jena uye protein yezai yolk. Uyezve, huwandu hweuric acid muserum hwakadzikira zviri pachena; uye zvakajairika kuti kudzikiswa kwehuwandu hwenitrogen isiri protein muserum kwaireva kuti kukurumidza kwecatabolism yeprotein kwakaderedzwa, uye nguva yekuchengetedza nitrogen yakamiswa. Mhedzisiro iyi yakapa hwaro hwekuwedzera kuchengetedza mapuroteni, kukurudzira kuisa mazai uye kuvandudza huremu hwezai rehuku dzinokandira mazai. Mhedzisiro yebvunzo yakaratidza kuti mhedzisiro yekukandira mazai yakanaka kwazvo kana 150mg/kg yediludine yakawedzerwa, izvo zvaienderana nemhedzisiro.[6,7]yaBao Erqing naQin Shangzhi uye yakawanikwa nekuwedzera diludine panguva yekupedzisira yekukandira huku. Mhedzisiro yacho yakaderedzwa kana huwandu hwe diludine hwaipfuura 150mg/kg, izvo zvinogona kunge zvichikonzerwa nekushandurwa kwemapuroteni.[8]yakakanganiswa nekuda kwemushonga wakawandisa uye mutoro wakawandisa wemetabolism yenhengo kuenda ku diludine.
3.2 Kuwanda kweCa2+Muropa rezai rinokandira mazamu, P muropa yakaderedzwa pakutanga uye basa reALP rakawedzerwa zviri pachena kana paine diludine, izvo zvakaratidza kuti diludine yakakanganisa metabolism yeCa neP zviri pachena. Yue Wenbin akataura kuti diludine inogona kukurudzira kunyudzwa kwemasero.[9] zvemaminerari Fe neZn; ALP yainyanya kuwanikwa munyama, dzakadai sechiropa, pfupa, ura, itsvo, nezvimwewo; ALP muropa yaibva muchiropa nepfupa; ALP mupfupa yainyanya kuwanikwa mu osteoblast uye yaigona kusanganisa phosphate ion neCa2 kubva muropa mushure mekushanduka nekukurudzira kuora kwephosphate nekuwedzera huwandu hwephosphate ion, uye yakaiswa papfupa muchimiro chehydroxyapatite, nezvimwewo kuitira kuti Ca neP zvideredzwe muropa, izvo zvinoenderana nekuwedzera kweukobvu hwegoko rezai uye huremu hwegoko rezai muzviratidzo zvemhando yezai. Uyezve, mwero wezai rakaputsika uye huwandu hwezai risina kujairika zvakadzikiswa pachena maererano nekushanda kwekuisa, izvo zvakatsanangurawo pfungwa iyi.
3.3 Kuiswa kwemafuta mudumbu uye huwandu hwemafuta muchiropa chehuku dzinoyamwisa zvakaderedzwa zviri pachena nekuwedzera diludine mukudya, izvo zvakaratidza kuti diludine ine simba rekudzora kugadzirwa kwemafuta mumuviri. Uyezve, diludine inogona kuvandudza mashandiro e lipase mu serum pakutanga; mashandiro e lipase akawedzerwa zviri pachena muboka iro 100mg/kg ye diludine yakawedzerwa, uye zviri mukati me triglyceride ne cholesterol mu serum zvakaderedzwa (p<0.01), izvo zvakaratidza kuti diludine inogona kukurudzira kuora kwe triglyceride uye kudzora kugadzirwa kwe cholesterol. Kuiswa kwemafuta kunogona kuderedzwa nekuti enzyme ye metabolism yemafuta muchiropa.[10,11], uye kudzikira kwecholesterol mu yolk yezai kwakatsanangurawo pfungwa iyi [13]. Chen Jufang akataura kuti diludine inogona kudzora kuumbwa kwemafuta mumhuka uye kuwedzera huwandu hwenyama isina mafuta yehuku nenguruve, uye ine simba rekurapa chiropa chine mafuta. Mhedzisiro yebvunzo yakajekesa mashandiro aya, uye mhedzisiro yekucheka nekutarisisa yehuku dzakaedzwa yakaratidzawo kuti diludine inogona kuderedza mwero wekuitika kwechiropa chine mafuta chehuku dzinoisa mazai zviri pachena.
3.4 GPT neGOT zviratidzo zviviri zvakakosha zvinoratidza mashandiro echiropa nemoyo, uye chiropa nemoyo zvinogona kukuvara kana mabasa acho akanyanya. Mabasa eGPT neGOT muropa haana kuchinjwa pachena kana diludine yawedzerwa mubvunzo, izvo zvakaratidza kuti chiropa nemoyo hazvina kukuvara; uyezve, mhedzisiro yekuyera yeSOD yakaratidza kuti mashandiro eSOD muropa anogona kuvandudzwa pachena kana diludine ikashandiswa kwenguva yakati. SOD inoreva chinhu chikuru chinobvisa superoxide free radical mumuviri; inokosha pakuchengetedza kusimba kwemembrane yemuviri, kuvandudza kugona kwekudzivirira muviri uye kuchengetedza hutano hwemhuka kana huwandu hweSOD mumuviri hwawedzera. Quh Hai, nezvimwewo, vakataura kuti diludine inogona kuvandudza mashandiro e6-glucose phosphate dehydrogenase mumembrane yemuviri uye kudzikamisa matishu [2] emasero emuviri. Sniedze akataura kuti diludine yakadzora mashandiro [4] eNADPH cytochrome C reductase zviri pachena mushure mekudzidza hukama huripo pakati pediludine neenzyme yakakodzera muNADPH specific electron transfer chain mu rat liver microsome. Odydents vakataurawo kuti diludine yaive nehukama [4] necomposite oxidase system uye microsomal enzyme ine chekuita neNADPH; uye mashandiro ekuita kwediludine mushure mekupinda mumhuka ndeekutamba basa rekudzivirira oxidation nekudzivirira biological membrane [8] nekudzivirira mashandiro e electron transfer NADPH enzyme ye microsome uye kudzora maitiro e peroxidation ye lipid compound. Mhedzisiro yebvunzo yakaratidza kuti basa rekudzivirira diludine ku biological membrane kubva pakuchinja kwebasa reSOD kuenda kukuchinja kwebasa reGPT neGOT uye yakaratidza mhedzisiro yekudzidza yeSniedze neOdydents.
Referensi
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2 Qu Hai, Lv Ye, Wang Baosheng, Mhedzisiro ye diludine yakawedzerwa pakudya kwezuva nezuva pahuwandu hwepamuviri uye kunaka kwembeu yetsuro yenyama.J. Chinyorwa cheChinese cheKurima Tsuro1994(6): 6-7
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9 Yue Wenbin, Zhang Jianhong, Zhao Peie, nezvimwewo. Chidzidzo chekuwedzera diludine nekugadzirira Fe-Zn pakudya kwezuva nezuva kwehuku dzinokandira mazai.Zvekudya neZvipfuyo1997, 18(7): 29-30
10 Mildner A na M, Steven D Clarke Porcine fatty acid synthase cloning yeDNA inowedzera, kugoverwa kwetishu yeRNA uye kudziviswa kwekutaura ne somatotropin neprotein yekudya J Nutri 1991, 121 900
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Nguva yekutumira: Chikumi-07-2021
