Tributyrin (TB)uyeMonolaurin (GML), sezvinhu zvinobatsira pakudya, zvine mhedzisiro yakawanda mumuviri mukurima huku dzine mazai, zvichivandudza zvakanyanya kugadzirwa kwemazai, kunaka kwemazai, hutano hwemudumbu, uye metabolism yemafuta mumuviri. Heano mabasa avo makuru uye mashandiro:

1. Kuvandudza mashandiro ekugadzira mazai
Glycerol Monolaurate(GML)

Kuwedzera 0.15-0.45g/kg GML pakudya kwehuku dzinoyamwisa kunogona kuwedzera zvakanyanya huwandu hwemazai, kuderedza huwandu hwekuchinjana kwechikafu, uye kuwedzera huremu hwemazai.
Ongororo inoratidza kuti 300-450mg/kg GML inogona kuvandudza huwandu hwemazai ehuku dzinokandira mazai uye kuderedza huwandu hwemazai asina kunaka.

Tributyrin (TB) 

Mukuyedza huku dzenyama dzemombe, 500mg/kg TB inogona kunonotsa kudzikira kwehuwandu hwemazai padanho rekupedzisira rekuisa mazai, kuwedzera simba remagoko emazai, uye kuderedza huwandu hwemazai anobuda.
Yakabatanidzwa neGML(senge fomura ine patent) inogona kuwedzera nguva yekuburitsa mazai akawanda uye kuwedzera mabhenefiti ehupfumi.

2. Kuvandudza kunaka kwemazai

Basa reGML
Wedzera hurefu hwemapuroteni, maHaff units (HU), uye wedzera ruvara rweyellow.
Gadzirisa chimiro chemafuta ari mu yolk yezai, wedzera polyunsaturated fatty acids (PUFA) uye monounsaturated fatty acids (MUFA), uye deredza huwandu hwemafuta akazara (SFA).

Pamuyero we300mg/kg, GML yakawedzera kuomarara kweganda rezai uye huwandu hweprotein chena yezai zvakanyanya.

Basa reTB

Wedzera simba remagoko emazai uye kuderedza mwero wekutyoka kwegoko (sekuderedza 58.62-75.86% mukuyedza).

Kurudzira kuratidzwa kwemajini ane chekuita nekuiswa kwecalcium muchibereko (senge CAPB-D28K, OC17) uye kuvandudza calcification yegoko remazai.

3. Kudzora kushandiswa kwemafuta mumuviri uye mashandiro ekudzivirira muviri
Basa reGML
Deredza triglycerides muropa (serum triglycerides) (TG), total cholesterol (TC), uye low-density lipoprotein cholesterol (LDL-C), uye kuderedza mafuta ari mudumbu.
Kuvandudza mashandiro e serum superoxide dismutase (SOD) uye glutathione peroxidase (GSH Px), kuderedza huwandu hwemalondialdehyde (MDA), uye kuwedzera kugona kweantioxidant.
Basa reTB
Deredza huwandu hwe triglyceride muropa (10.2-34.23%) uye wedzera majini ane chekuita nekuoxidation yemafuta (akadai seCPT1).
Deredza mazinga e serum alkaline phosphatase (AKP) neMDA, uye wedzera huwandu hwe antioxidant (T-AOC).

4. Kuvandudza hutano hwemudumbu
Basa reGML
Wedzera hurefu hwevillus uye chiyero chevillus kune villus (V/C) chejejunum kuti uvandudze chimiro chemudumbu.
Deredza zvinhu zvinorwisa kuzvimba (zvakaita seIL-1 β, TNF-α), wedzera zvinhu zvinorwisa kuzvimba (zvakaita seIL-4, IL-10), uye wedzera mashandiro ekudzivirira dumbu.
Gadzirisa chimiro che cecal microbiota, deredza huwandu hweProteobacteria, uye kurudzira kukura kwemabhakitiriya anobatsira akadai seSpirogyraceae.
Basa reTB
Gadzirisa pH yemudumbu, kurudzira kuwanda kwemabhakitiriya anobatsira (akadai selactobacilli), uye kudzivirira mabhakitiriya anokuvadza.
Kuwedzera kwemapuroteni e tight junction (akadai seOccludin, CLDN4) kunowedzera kusimba kwezvipingamupinyi zvemudumbu.

5. Kudzora kwemasimba ekudzivirira muviri
Mashandiro eGML
Kuvandudza spleen index uye thymus index, kusimudzira mashandiro emuviri.
Deredza zviratidzo zvekuzvimba muropa zvakaita se aspartate aminotransferase (AST) uye alanine aminotransferase (ALT).
Basa reTB
Deredza kuzvimba kwemudumbu nekutonga nzira yeToll-like receptor (TLR2/4).

6. Mhedzisiro yekushandisa pamwe chete
Ongororo yepatenti yakaratidza kuti musanganiswa weGML neTB (yakadai se20-40 TB+15-30 GML) inogona kuvandudza huwandu hwemazai ehuku dzinokandira mazai (92.56% vs. 89.5%), kuderedza kuzvimba kwemachubhu, uye kuwedzera nguva yekugadzirwa kwemazai.

Pfupiso:

Glycerol Monolaurate (GML)uyeTributyrin (TB)zvine zvazvinobatsira pakurima huku:

GMLinotarisa pakunatsiridza kunaka kwezai, kudzora kushandiswa kwemafuta mumuviri, uye kushanda kweantioxidant;
TBinotarisa pakunatsiridza hutano hwemudumbu uye calcium metabolism;
Musanganiswa wacho unogonazvinoshandisa simba rekubatsirana, zvinovandudza zvizere mashandiro ekugadzira uye kunaka kwemazai.